Tomocube, Inc.

Tomocube’s is dedicated to delivering products that can enhance biological and medical research via novel optical solutions that can assist Tomocube in understanding, diagnosing, and treating human diseases.
Current optical microscopes only provide users with a 2D view of their sample. To get a 3D view, users must use expensive and invasive electron or confocal microscopes, which require extensive pre-preparation of samples and are not amenable to dynamic samples such as live cells. Our platform enables researchers to measure nanoscale, real-time, dynamic images of individual living cells without the need for sample preparation.

Our product, the HT-1, measures 3D refractive index tomograms of live cells and tissues, which will enable researchers and clinicians to:
(1) non-invasively observe label-free 3D dynamics of live cells and tissues (2) retrieve unique cell properties including cell volume, shapes of sub-cellular organelles, cytoplasmic density, surface area, and deformability and (3) quantitatively study cell pathophysiology and efficacy of drugs.

HT-1 uses states-of-the-art digital holographic techniques, quantitative phase imaging techniques and 3D reconstruction & cell analysis algorithms in order to display high-resolution 3D refractive index tomograms of cells.